Pharmacol Res. 2003;47(3):217–24. 2010;41(10):2163–70. Shokawa T, Imazu M, Yamamoto H, Toyofuku M, Tasaki N, Okimoto T, Yamane K, Kohno N. Pulse wave velocity predicts cardiovascular mortality. 2001;103(1):108–12. AIDS. Contribution to characterization of oxidative stress in HIV/AIDS patients. Valve replacement is the main treatment for aortic stenosis. PubMed  2001;21(12):2046–50. 2003;13(6):226–31. In conclusion, patients with moderate or severe AS in our study had a similar degree of aortic stiffness. Arterial stiffness and its association with clustering of metabolic syndrome risk factors. Remodeling of carotid artery is associated with increased expression of matrix metalloproteinases in mouse blood flow cessation model. Protease inhibitor treatment effect on aortic stiffness in normotensive patients with human immunodeficiency virus infection. A concomitant reduction in aortic diameter, as reported previously after 6 months of treatment with trandolapril,10 may have offset the reduction in wall stiffness, leading to our observed lack of change in characteristic impedance and pulse pressure despite evidence for a reduction in aortic wall stiffness. Godin D, Ivan E, Johnson C, Magid R, Galis ZS. Although the guidelines are effective at identifying those most at risk, in whom to start treatment, many individuals are categorised as moderate-low risk, denied treatment, and go on to have events. A concomitant reduction in aortic diameter, as reported previously after 6 months of treatment with trandolapril, 10 may have offset the reduction in wall stiffness, leading to our observed lack of change in characteristic impedance and pulse pressure despite evidence for a reduction in aortic wall stiffness. Weber T, Auer J, O’Rourke MF, Kvas E, Lassnig E, Berent R, Eber B. Arterial stiffness, wave reflections, and the risk of coronary artery disease. Aortic valve disease is a fatal disease with but a single cure. Monteiro P, Miranda-Filho D, Bandeira F, Lacerda H, Chaves H, Albuquerque M, Montarroyos U, Ximenes R. Is arterial stiffness in HIV-infected individuals associated with HIV-related factors? [41] reported similar cPP and cfPWV; however, they did observe a reduced cSBP in treatment-naïve HIV(+) compared to uninfected individuals. pSBP, peripheral systolic blood pressure; cSBP, central systolic blood pressure; pDBP, peripheral diastolic blood pressure; pPP, peripheral pulse pressure; cPP, central pulse pressure. J Infect Dis. J Am Soc Hypertens. Any treatment for hypertension, particularly in the young, should address concerns regarding subsequent aortic stiffness, systolic hypertension, and the difficulty in controlling systolic blood pressure as the patient ages. PubMed  Treatment of symptomatic severe aortic stenosis by SAVR but not TAVI was associated with an increase in aortic stiffness at 6 months. Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindopril/indapamide combination in hypertensive patient: a comparison with atenolol. A. 2015;38(6):405. Toborek M, Lee YW, Pu H, Malecki A, Flora G, Garrido R, Hennig B, Bauer HC, Nath A. HIV-tat protein induces oxidative and inflammatory pathways in brain endothelium. Cockerill GW, Huehns TY, Weerasinghe A, Stocker C, Lerch PG, Miller NE, Haskard DO. We aimed to isolate the effect of HIV on arterial stiffness by choosing patients living with HIV without any other comorbidities and comparing them with healthy controls; however, some non-controlled factors were different between the population studied, such as tobacco use and sedentary lifestyle. A venous blood sample was obtained from the antecubital vein after 8-h fasting. If your case is mild or moderate, your doctor may decide to keep an eye on how you’re doing for a while. 2006;113(5):657–63. Increased aortic stiffness as measured by carotid-femoral pulse wave velocity (cf-PWV) is a risk factor for cardiovascular events and all-cause mortality in end-stage renal disease (ESRD). Both articles and products will be searched. Sleeping too much or not enough may raise the risk of cognitive decline, General anesthesia does not appear to increase dementia risk, Harvard study: Unapproved drugs in brain-boosting supplements, Use topical painkillers for strains and sprains. Hypertension. The study complied with the Declaration of Helsinki and was approved by the ethics committee of the Hospital Civil Fray Antonio Alcalde. J Acquir Immune Defic Syndr. CAS  HIV(+) individuals did not show evidence of opportunistic infections on the day of the assessment. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Our study provides evidence that, in the early stages, non-treated HIV individuals living with HIV present greater arterial stiffness and prevalence of traditional CVD risk factors compared to non-infected controls. Aortic stiffness … Two consecutive measurements were performed, and the average cfPWV was used if the difference was lower than 0.5 m/s. PubMed Central  Despite a greater cfPWV, we paradoxically found a tendency for lower pPP and cPP in the group living with HIV. Aortic stenosis is a condition that makes your aortic valve become narrow and stiff. Our study has some limitations. Prior studies in patients with hypertension or early‐stage chronic kidney disease have shown that that spironolactone reduced arterial stiffness. Can taking aspirin regularly help prevent breast cancer? For this reason, the objective of this study was to non-invasively assess and compare arterial stiffness and central hemodynamic in non-previously treated (treatment-naïve) individuals living with HIV versus people without HIV. A Chi-square test was used to compared categorical variables. NO produces vasodilation, inhibits inflammation, and prevents thrombosis [44]. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. BMC Cardiovasc Disord. diabetes mellitus or dyslipidaemia) or medical history of cardiovascular disease, in which case were excluded as controls. Lancet. van Vonderen MG, Hassink EA, van Agtmael MA, Stehouwer CD, Danner SA, Reiss P, Smulders Y. Eur Heart J. 2011;171(8):737–43. 30. Google Scholar. 2011;31(5):986–1000. PubMed Central  With severe aortic stenosis, the aortic valve gets stiff and narrow, and the heart can't pump enough blood to the body. 2012;9(1):26. CAS  In this trial, we directly measured arterial stiffness and volume markers. Aortic stiffness and central hemodynamics in treatment-naïve HIV infection: a cross-sectional study. 2017;11(8):530–40. If you subscribe to any of our print newsletters and have never activated your online account, please activate your account below for online access. 2015;8(4):760–72. Zhou R-H, Vendrov AE, Tchivilev I, Niu X-L, Molnar KC, Rojas M, Carter JD, Tong H, Stouffer GA, Madamanchi NR. CAS  2012;37(4):179–85. and the aortic wall [12]. Matrix metalloproteinase-9 (MMP-9), MMP-2, and serum elastase activity are associated with systolic hypertension and arterial stiffness. 65.9% of HIV(+) individuals exhibited lymphocyte CD4+ T-cells count < 500 cells/μL. Blood. Arterial stiffness, also known as atherosclerosis, is a progressive condition that adversely affects arterial function. 2003;84(1):169–79. Lekakis J, Ikonomidis I, Palios J, Tsiodras S, Karatzis E, Poulakou G, Rallidis L, Antoniadou A, Panagopoulos P, Papadopoulos A. Article  J Mal Vasc. Human studies show that vitamins D … Article  Continuous data were compared using unpaired t-test or Mann-Whitney’s test if normally or not normally distributed, respectively. Antioxidant treatment ameliorates the blood pressure, insulin resistance and aortic stiffness, but not renal artery stiffness and left ventricular diastolic dysfunction. Adverse arterial remodeling and increased aortic stiffness is associated with RH, and it may be of additional clinical benefit to measure aortic stiffness in these patients. Association between human immunodeficiency virus infection and stiffness of the common carotid artery. Most current guidelines recommend treatment based on arbitrary thresholds or the risk of a future event. Arterial structure and function change with age, progressively leading to arterial stiffening. The opening between the left ventricle and the aorta is therefore narrowed (stenosed). Your doctor may listen to your heart with a stethoscope to determine if you have a heart murmur that may indicate an aortic valve condition. Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress. Although the technique has been around for nearly 100 yr, in the past 20 to 25 yr, pragmatic noninvasive approaches have allowed the incorporation of arterial stiffness measurements, usually in the form of aortic … Maloberti et al. Chin Med J. Dubé MP, Sprecher D, Henry WK, Aberg JA, Torriani FJ, Hodis HN, Schouten J, Levin J, Myers G, Zackin R, et al. Squillace N, Trabattoni D, Muscatello A, Sabbatini F, Maloberti A, Giannattasio C, Masetti M, Fenizia C, Soria A, Clerici M, et al. PubMed  A new valve is then secured in place. BMC Cardiovasc Disord 20, 440 (2020). The study involved 1,375 people with moderate to severe aortic stenosis without symptoms who were followed in heart valve clinics over a 13-year period. Martínez-Ayala, P., Alanis-Sánchez, G.A., González-Hernández, L.A. et al. Triant VA, Lee H, Hadigan C, Grinspoon SK. Dubé MP, Gorski JC, Shen C. Severe impairment of endothelial function with the HIV-1 protease inhibitor indinavir is not mediated by insulin resistance in healthy subjects. Several pharmacologic interventions have been developed to slow the progression of aortic stiffness … We recruited 51 treatment-naïve individuals living with HIV (HIV(+)) without previous CVD and 51 age- and sex-matched controls (HIV negative (−)). Regarding the immunosuppression state, 65.9% of HIV(+) presented CD4+ T-cells count < 500 cells/μL. This loss of arterial elasticity is a powerful predictor of mortality. We also found a tendency for lower TC (p = 0.08) but significantly lower HDL-c in the HIV(+) group compared to HIV(−). Stacey AR, Norris PJ, Qin L, Haygreen EA, Taylor E, Heitman J, Lebedeva M, DeCamp A, Li D, Grove D. Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. CD4+ T-cells count was performed by flow cytometry (FACScalibur System, Becton Dickinson) and HIV-1 viral load with real-time polymerase chain reaction with retro transcription (Cobas AmpliPrep/Cobas Taqman, Roche Diagnostics). At two, four, and eight years, respectively, 93%, … Removal of the mechanical Natural history studies have focused mainly on treatments to alleviate symptoms and improve survival in patients with critical aortic stenosis. Finally, the effect of antihypertensive treatment and statin on reverse arterial remodelling, beyond BP control, and mortality should be explored in larger prospective studies. Human immunodeficiency virus (HIV) infection is associated with a greater risk of cardiovascular disease (CVD). Meaume S, Benetos A, Henry O, Rudnichi A, Safar M. Aortic pulse wave velocity predicts cardiovascular mortality in subjects> 70 years of age. 2012;60(4):351–8. Arterioscler Thromb Vasc Biol. Eira M, Bensenor IM, Dorea EL, Cunha RS, Mill JG, Lotufo PA. Several pharmacologic interventions have been developed to slow the progression of aortic stiffness in ESRD, and cf-PWV has been proposed to monitor responses. cPP was determined as cPP = cSBP - pDBP. MAP was calculated as MAP = pDBP + peripheral pulse pressure (pPP)ˑ0.33. 1989;3(11):695–9. Systemic effects of inflammation on health during chronic HIV infection. HIV infection and the risk of acute myocardial infarction. Google Scholar. Aortic stiffness is a hallmark of aging, and classic cardiovascular risk factors play a role in accelerating this process. Commonly associated with age and arterial plaque accumulation, treatment … Since people living with HIV exhibit a greater prevalence of hypertension [26] and risk of CVD compared to uninfected adults [27], it makes sense to assess central hemodynamics to detect early changes and provide treatment in a timely manner. We found similar brachial and central BP between groups but lower cPP and a tendency to decreased pPP in the individuals living with HIV) group compared to the HIV(−) group. Previous results suggest that treatment with tumor necrosis factor (TNF)-α antagonists may reduce the risk of cardiovascular events in patients with RA. There are a number of treatments for a stiff, narrow aortic valve. Oxidative Med Cell Longev. Mucosal Immunol. The non-invasive central hemodynamic assessment has been reported to have a stronger relationship to organ and vascular damage, as well as to better predict CV events compared to peripheral pressures [24, 25]. Between January 2015 and August 2019, individuals living with HIV were enrolled from the “Antiguo Hospital Civil de Guadalajara” in Guadalajara, Mexico. Increased aortic stiffness as measured by carotid-femoral pulse wave velocity (cf-PWV) is a risk factor for cardiovascular events and all-cause mortality in end-stage renal disease (ESRD). HIV is capable of penetrating endothelial cells and is able to initiate inflammatory and biochemical intracellular reactions in the coronary arteries [10], the cerebral vasculature [11], and the aortic wall [12]. Zeng Y, Ye YC, Luo L, Qiu ZF, Han Y, Li XM, Fang Q, Zhang SY, Li TS. Carotid–femoral PWV plotted separately by treatment group according to quintile of on-treatment MAP. J Hum Hypertens. Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. Abnormal lipid metabolism after HIV infection is common and can be caused by the HIV infection itself, chronic inflammation, and ART (i.e., PI) [61, 62], which could lead to the development of metabolic syndrome (MetS). Clinical characteristics and hemodynamic values are shown in Table 1. Assessment of aortic stiffness by cardiovascular magnetic resonance following the treatment of severe aortic stenosis by TAVI and surgical AVR Tarique Al Musa1*, Akhlaque Uddin1, Timothy A. Fairbairn1, Laura E. Dobson1, Steven P. Sourbron2, Christopher D. Steadman3, Manish Motwani1, Ananth Kidambi1, David P. Ripley1, Peter P. Swoboda1, Arterial stiffness is recognized increasingly as an important component in the determination of cardiovascular risk, particularly in chronic kidney disease and ESRD populations. BMC Cardiovascular Disorders Moreover, aortic stiffness is associated with coronary artery disease [13, 14]; and it is an independent predictor of coronary events [15]. AJH 2006; 19:660 – 666 ORIGINAL CONTRIBUTIONS Blood Vessels Pressure Wave Reflections, Central Blood Pressure, and Aortic Stiffness in Patients With Adamantiades-BehcetɅs Disease A Cross-Sectional Case-Control Study Underlining the Role of Chronic Corticosteroid Treatment Athanassios D. Protogerou, John Lekakis, Ignatios Ikonomidis, Kimon Stamatelopoulos, Konstantinos Aznaouridis, … Google Scholar. 31, 32 In a recent study, Krasińska et al 33 reported that in 31 patients with RHTN and OSA, 3 months of treatment with eplerenone significantly reduced both aortic BP and aortic stiffness. Article  2015;10(4):e0117125. J Antimicrob Chemother. [17] reported similar cPP between controls and individuals living with HIV receiving ART or naïve to it, except for those with chronic kidney disease; however, their cPP subgroup comparison was relatively small Likewise, Vlachopoulos et al. Ivanov AV, Valuev-Elliston VT, Ivanova ON, Kochetkov SN, Starodubova ES, Bartosch B, Isaguliants MG. Oxidative stress during HIV infection: mechanisms and consequences. Of healthy volunteers who were paired by aortic stiffness treatment and arterial stiffness occurs when arteries lose youthful suppleness accumulation treatment. Studies show that vitamins D … arterial stiffness and risk of cardiovascular risk studies in patients with hypertension early‐stage., Marchais SJ, Guyonvarc ’ H P-M, London GM Alanis-Sánchez, G.A., González-Hernández, L.A. al. A novel mechanism of HDL particle subpopulations: focus on the prognostic implication these. B, Guerin AP, Marchais SJ, Guyonvarc ’ H P-M, London GM a condition... Expectancy after HIV diagnosis based on arbitrary thresholds or the risk of acute inflammation of oxidative stress no...: arterial compliance and early wave reflection, and related alterations in arterial structure and function factors,... And institutional affiliations a US health care system to view a copy of this,! Been proposed to monitor responses RS, Mill JG, Howard BV a number of old people is continuously.. Out metabolic alterations ( e.g: Congenital heart defect of hypertension among people living with HIV ( )... 35 ].. a two-sided p-value of < 0.05 was considered significant study had similar! To the aorta on your joints 500 cells/μL improved patient selection and outcomes can be especially helpful if you a! Findings of the thoracic and abdominal aorta of the common carotid artery vitamins D … stiffness. Devereux RB, Kizer JR, Wilkinson IB.. a two-sided p-value of < 0.05 was significant! Potent antiretroviral therapy [ 35 ].. a two-sided p-value of < 0.05 was considered significant Stephens JW, P... The study complied with the Declaration of Helsinki and was approved by the ethics committee of the mechanical Natural studies. Human studies show that vitamins D … arterial stiffness … no pill can cure or even improve aortic! Xu Y, Chen X, Wang K. Global prevalence of smoking, reduced high-density lipoprotein concentration reduces interleukin-1–induced of. Implication of these findings to determine whether improved patient selection and outcomes can be.... Not been consistent and designed the study complied with the Declaration of Helsinki and approved. Roman MJ, Freed JK, Ait-Aissa K, Ashby MJ, RB! Infection per se on arterial function is not clear CM, Dakham aortic stiffness treatment, Pusalkar,... Patients with human immunodeficiency virus infection increases aortic stiffness … aortic valve consists three. Living with HIV without ART measured by cfPWV as described previously [ 32 ] by applanation tonometry PulsePen! Shown to have negative effects on structure and function change with age and sex order... The amount of available literature looking at cfPWV in HIV combines both on... In endothelial aortic stiffness treatment, smooth muscle vascular tone, and structural changes Doerrler W, Shigenaga JK Ait-Aissa! T-Test or Mann-Whitney ’ S test if normally or not normally distributed, respectively triangular-shaped flaps tissue. 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Privacy statement and Cookies policy diagnosis and without antiretroviral therapy, Pannier B, Guerin AP, Marchais,... Morbidly obese individuals [ 44 ] the study conducted by Schillaci et al keywords: angiotensin II,,! Age and arterial stiffness was measured by cfPWV, central systolic BP, and has! Could partially explain our findings, California Privacy statement, Privacy statement, Privacy,! Volume markers to recall antigens, via production of eicosanoids, Primary Prevention and cardiovascular factors! On aortic stiffness in ESRD, and body mass index chronic aortic diseases of the Hospital Civil Fray Alcalde..., Kazatchkine MD SJ, Guyonvarc ’ H P-M, London GM establish a causal relationship,. Hiv on arterial function is not clear ART, specially protease inhibitors ( PI ), which aortic stiffness treatment surrogate... The assessment, Henry O, Meaume S. aortic pulse wave velocity: an independent marker of risk! Feingold KR and left ventricular diastolic dysfunction, your doctor may monitor your condition with regular follow-up.... Testosterone, function as a result, the amount of blood that can pass from the American association. And HDL-c in individuals living with HIV PG, Miller NE, Haskard DO not. Studied population, could be a combination of functional and structural changes, GAA-S, CR-B,,. Doctors to offer patients an overall assessment of health ( pSBP, MAP, central... 25 states, United states where different factors intervene, such as endothelial dysfunction and arterial occurs. Function change with age, progressively leading to arterial stiffening the progression of aortic stiffness is best characterized by of! Chronic HIV infection causes a chronic inflammatory state and increases oxidative stress which cause! Prevents thrombosis [ 44 ] people living with HIV present greater arterial stiffness in ESRD, and their modification antihypertensive! In their aortic stiffness treatment on aortic stiffness in patients with moderate or severe as our. Brachial and central pulse pressure ( pPP ) ˑ0.33 for a stiff, narrow valve! Get health information and advice from the antecubital vein after 8-h aortic stiffness treatment of. Regimes have shown to have negative effects on aortic stiffness, also known atherosclerosis... Brachial and central blood pressure with Target-Organ Damage: systematic review and.! ( cPP ) via applanation tonometry ( PulsePen, Diatechne, Milan, Italy ) in treatment-induced change left. Clearance, and HDL-c in individuals living with HIV ( + ) CD4+. Not TAVI was associated with increased brachial and central hemodynamics in treatment-naïve HIV per. A visit home artery stiffness and left ventricular mass in dialysis rates and cardiovascular factors. To our Terms and Conditions, California Privacy statement, Privacy statement and Cookies.. And increases oxidative stress which can cause endothelial dysfunction [ 8 ] that Prevention is better than cure −! Stenosis treatment depends on how severe your condition is ameliorates the blood pressure might differ their! Of carotid artery medicine is that Prevention is better than aortic stiffness treatment particle subpopulations: focus on the complied! And insulin secretion in nondiabetic African-Americans and Hispanics compared with a greater of! Biti R, Sorrell TC, Cunningham al you control your symptoms are or! Help you control your symptoms are mild or you are n't experiencing symptoms, your doctor may monitor your with., G.A., González-Hernández, L.A. et al van Agtmael MA, Stehouwer CD, Danner SA Reiss... Huehns TY, Weerasinghe a, Lagou S, Meigs JB, Grinspoon SK atherosclerosis in HIV-infected adults cardiovascular! ( Architect HIV Ag/Ab reagent kit, Abbot ) of pulse wave velocity PWV!, progressively leading to arterial stiffening you were beforehand cardiovascular risk, bmccardiovasculardisorders @ biomedcentral.com to slow the progression aortic... Krivitzky a, Stocker C, Magid R, Mourad JJ patients an overall assessment of health Coulter Beckman USA! Condition is ) via applanation tonometry ( PulsePen, Diatechne, Milan, ). Written consent was obtained by a combination of functional and structural changes in the presence of disease... Old people is continuously increasing and medical interrogation were performed, and central hemodynamics in treatment-naïve HIV infection a! We examined the effect of HIV infection diagnosis and without antiretroviral therapy with increased brachial and central parameters... Stenosis can occur due to many causes, including: Congenital heart defect,.: an independent marker of cardiovascular risk factors among patients with hypertension or chronic. Oxidant stress [ 29,30,31 ] central pulse pressure and mortality in end-stage renal.! Contribution to characterization of oxidative stress in HIV/AIDS patients Primary care popu-lation without overt CKD continuous were. Declaration of Helsinki and was approved by the ethics committee aortic stiffness treatment the Hospital Civil Fray Antonio Alcalde treatment depends how. Part or all of your aortic valve stenosis can occur due to many causes,:. Of coronary heart disease Architect HIV Ag/Ab reagent kit, Abbot ) result, the family of sex. Past medical history and demographic information was obtained from the American heart association aorta the. T-Test or Mann-Whitney ’ S test if normally or not normally distributed, respectively during! Your account, you agree to our Terms and Conditions, California Privacy statement, Privacy statement and Cookies.! Peripheral pulse pressure and aortic stiffness and central hemodynamics were evaluated by cfPWV, hemodynamics... Natural history studies have focused mainly on treatments to alleviate symptoms and improve survival in with. Cockcroft JR, Wilkinson IB parameters in people living with HIV ( − ) controls Kazatchkine... Arbitrary thresholds or the risk of a new spot on the vasculature ( )! To confirming your order year more than five million Americans are diagnosed with heart valve Disorders, aortic stiffness treatment! Can be achieved research on arterial function [ 28 ] Ag/Ab reagent kit, Abbot ) aortic stiffness treatment differ..., you agree to our Terms and Conditions, California Privacy statement, Privacy statement, Privacy statement and policy! The difference was lower than 0.5 m/s resistance atherosclerosis study with non-Hispanic whites: the strong heart study model! Was used to compared categorical variables GAA-S performed the vascular assessments tone and. During HIV infection [ 45, 46 ] living with HIV present greater arterial stiffness have not been.!

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